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1

Nanoparticulation of Poorly Water Soluble Drugs Using a Wet-Mill Process and Physicochemical Properties of the Nanopowders

Tanaka, Yusuke, Inkyo, Mitsugi, Yumoto, Ryoko, Nagai, Junya, Takano, Mikihisa, Nagata, Shunji

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2009

Language:

english

File:

PDF, 1.89 MB

english, 2009

2

Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function

Denpong Patanasethanont, Junya Nagai, Ryoko Yumoto, Teruo Murakami, Khaetthareeya Sutthanut, Bung-orn Sripanidkulchai, Chavi Yenjai, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 203 KB

english, 2007

3

Expression and function of efflux drug transporters in the intestine

Mikihisa Takano, Ryoko Yumoto, Teruo Murakami

Journal:

Pharmacology & Therapeutics

Year:

2006

Language:

english

File:

PDF, 448 KB

english, 2006

4

Effects of endocytosis inhibitors on internalization of human IgG by Caco-2 human intestinal epithelial cells

Koya Sato, Junya Nagai, Naoko Mitsui, Ryoko Yumoto, Mikihisa Takano

Journal:

Year:

2009

Language:

english

File:

PDF, 470 KB

english, 2009

5

Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and β-methyldigoxin in rats

Sachiyo Funakoshi, Teruo Murakami, Ryoko Yumoto, Yoshie Kiribayashi, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2003

Language:

english

File:

PDF, 119 KB

english, 2003

6

Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human

Kei Omoda, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Yorinobu Maeda, Yoshie Kiribayashi, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 125 KB

english, 2005

7

Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and β-methyldigoxin in rats

Sachiyo Funakoshi, Teruo Murakami, Ryoko Yumoto, Yoshie Kiribayashi, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 117 KB

english, 2005

8

Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine

Ryoko Yumoto, Shota Hamada, Kaori Okada, Yuki Kato, Mika Ikehata, Junya Nagai, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 176 KB

english, 2009

9

Accumulation and photodynamic activity of chlorin e6 in cisplatin-resistant human lung cancer cells

Sayo Horibe, Junya Nagai, Ryoko Yumoto, Riichi Tawa, Mikihisa Takano

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 221 KB

english, 2011

10

Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes

Kumiko Ogawa, Ryoko Yumoto, Natsuki Hamada, Junya Nagai, Mikihisa Takano

Journal:

Epilepsy Research

Year:

2006

Language:

english

File:

PDF, 434 KB

english, 2006

11

Comparison of Albumin Uptake in Rat Alveolar Type II and Type I-like Epithelial Cells in Primary Culture

Mika Ikehata, Ryoko Yumoto, Kosuke Nakamura, Junya Nagai, Mikihisa Takano

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 625 KB

english, 2008

12

Mutation of epidermal growth factor receptor is associated with MIG6 expression

Takeshi Nagashima, Ryoko Ushikoshi-Nakayama, Atsushi Suenaga, Kaori Ide, Noriko Yumoto, Yoshimi Naruo, Kaoru Takahashi, Yuko Saeki, Makoto Taiji, Hiroshi Tanaka, Shih-Feng Tsai, Mariko Hatakeyama

Journal:

Year:

2009

Language:

english

File:

PDF, 1018 KB

english, 2009

13

Pharmacokinetic Analysis of the Absorption Enhancing Action of Decanoic Acid and Its Derivatives in Rats

Koji Takahashi, Teruo Murakami, Atsuko Kamata, Ryoko Yumoto, Yutaka Higashi, Noboru Yata

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 784 KB

1994

14

Decanoic Acid Induced Enhancement of Rectal Absorption of Hydrophilic Compounds in Rats

Koji Takahashi, Teruo Murakami, Ryoko Yumoto, Tomomi Hattori, Yutaka Higashi, Noboru Yata

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 666 KB

1994

15

Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells

Tomoharu Yokooji, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Mikihisa Takano

Journal:

Journal of Pharmacy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 543 KB

english, 2007

16

Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats

Tomoharu Yokooji, Teruo Murakami, Kumiko Ogawa, Ryoko Yumoto, Junya Nagai, Mikihisa Takano

Journal:

Journal of Pharmacy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

17

Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats

Tomoharu Yokooji, Ryoko Yumoto, Junya Nagai, Mikihisa Takano, Tomoharu Yokooji, Teruo Murakami

Journal:

Journal of Pharmacy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 486 KB

english, 2007

18

Segment-selective absorption of lysozyme in the intestine

Mikihisa Takano, Yuka Koyama, Hiromi Nishikawa, Teruo Murakami, Ryoko Yumoto

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 259 KB

english, 2004

19

Function of multidrug resistance-associated protein 2 in acute hepatic failure rats

Tomoharu Yokooji, Teruo Murakami, Ryoko Yumoto, Junya Nagai, Mikihisa Takano

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 350 KB

english, 2006

20

Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components

Denpong Patanasethanont, Junya Nagai, Chie Matsuura, Kyoko Fukui, Khaetthareeya Sutthanut, Bung-orn Sripanidkulchai, Ryoko Yumoto, Mikihisa Takano

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 435 KB

english, 2007

21

Mechanism underlying insulin uptake in alveolar epithelial cell line RLE-6TN

Keisuke Oda, Ryoko Yumoto, Junya Nagai, Hirokazu Katayama, Mikihisa Takano

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

22

Gadolinium modulates gentamicin uptake via an endocytosis-independent pathway in HK-2 human renal proximal tubular cell line

Takeshi Sawada, Junya Nagai, Yumi Okada, Ryoko Yumoto, Mikihisa Takano

Journal:

European Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 986 KB

english, 2012

23

Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides

Junya Nagai, Masaki Saito, Yoshinori Adachi, Ryoko Yumoto, Mikihisa Takano

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 178 KB

english, 2006

24

Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure

Zhao-Hui Huang, Teruo Murakami, Atsuko Okochi, Ryoko Yumoto, Junya Nagai, Mikihisa Takano

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 179 KB

english, 2000

25

Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells

Mikihisa Takano, Risa Hasegawa, Takeshi Fukuda, Ryoko Yumoto, Junya Nagai, Teruo Murakami

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 191 KB

english, 1998

26

Enhancing effect of 5 α-cyprinol sulfate on mucosal membrane permeability to sodium ampicillin in rats

Teruo Murakami, Kaoru Ohoku, Ryoko Yumoto, Michiko Yoshii, Mizuho Une, Taiju Kuramoto, Takahiko Hoshita, Noboru Yata

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2000

Language:

english

File:

PDF, 190 KB

english, 2000

27

Biopharmaceutics: Topical Delivery of Keloid Therapeutic Drug, Tranilast, by Combined Use of Oleic Acid and Propylene Glycol as a Penetration Enhancer: Evaluation by Skin Microdialysis in Rats

TERUO MURAKAMI, MAKIKO YOSHIOKA, RYOKO YUMOTO, YUTAKA HIGASHI, SADAYUKI SHIGEKI, YOSHIKAZU IKUTA, NOBORU YATA

Journal:

Journal of Pharmacy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 571 KB

english, 1998

28

Biopharmaceutics: Effect of Ointment Bases on Topical and Transdermal Delivery of Salicylic Acid in Rats: Evaluation by Skin Microdialysis

TERUO MURAKAMI, MAKIKO YOSHIOKA, ICHIRO OKAMOTO, RYOKO YUMOTO, YUTAKA HIGASHI, KAYO OKAHARA, NOBORU YATA

Journal:

Journal of Pharmacy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 640 KB

english, 1998

29

N-Acetyl-L-γ-glutamyl Derivatives of p-Nitroaniline, Sulphamethoxazole and Sulphamethizole for Kidney-specific Drug Delivery in Rats

TERUO MURAKAMI, KUMIKO KOHNO, RYOKO YUMOTO, YUTAKA HIGASHI, NOBORU YATA

Journal:

Journal of Pharmacy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 647 KB

english, 1998

30

Effect of Cigarette Smoke Extract on Insulin Transport in Alveolar Epithelial Cell Line A549

Takano, Mikihisa, Horiuchi, Taishi, Nagai, Junya, Yumoto, Ryoko

Journal:

Year:

2012

Language:

english

File:

PDF, 512 KB

english, 2012

31

Effect of protamine on the accumulation of gentamicin in opossum kidney epithelial cells

Nagai, Junya, Komeda, Takuji, Yumoto, Ryoko, Takano, Mikihisa

Journal:

Journal of Pharmacy and Pharmacology

Year:

2013

Language:

english

File:

PDF, 542 KB

english, 2013

32

Modulation of insulin transport by D-glucose in alveolar epithelial cells

Oda, Keisuke, Yumoto, Ryoko, Nagai, Junya, Takano, Mikihisa

Journal:

Biomedicine & Aging Pathology

Year:

2013

Language:

english

File:

PDF, 1.12 MB

english, 2013

33

Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line

Nagai, Junya, Yamamoto, Ayaka, Yumoto, Ryoko, Takano, Mikihisa

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 655 KB

english, 2013

34

Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells

Takano, Mikihisa, Horiuchi, Taishi, Sasaki, Yoshihiro, Kato, Yuki, Nagai, Junya, Yumoto, Ryoko

Journal:

Year:

2013

Language:

english

File:

PDF, 793 KB

english, 2013

35

Fatty acid-bearing albumin but not fatty acid-depleted albumin induces HIF-1 activation in human renal proximal tubular epithelial cell line HK-2

Nagai, Junya, Yamamoto, Ayaka, Katagiri, Yuki, Yumoto, Ryoko, Takano, Mikihisa

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 675 KB

english, 2014

36

Effect of PEGylation of N-WASP181-200 on the Inhibitory Potency for Renal Aminoglycoside Accumulation

Fujii, Kenji, Nagai, Junya, Sawada, Takeshi, Yumoto, Ryoko, Takano, Mikihisa

Journal:

Bioconjugate Chemistry

Year:

2009

Language:

english

File:

PDF, 392 KB

english, 2009

37

Analysis of TGF-β1- and drug-induced epithelial–mesenchymal transition in cultured alveolar epithelial cell line RLE/Abca3

Takano, Mikihisa, Yamamoto, Chieko, Yamaguchi, Koki, Kawami, Masashi, Yumoto, Ryoko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 892 KB

english, 2015

38

Nanoparticulation of probucol, a poorly water-soluble drug, using a novel wet-milling process to improve in vitro dissolution and in vivo oral absorption

Tanaka, Yusuke, Inkyo, Mitsugi, Yumoto, Ryoko, Nagai, Junya, Takano, Mikihisa, Nagata, Shunji

Journal:

Drug Development and Industrial Pharmacy

Year:

2012

Language:

english

File:

PDF, 1003 KB

english, 2012

39

Cisplatin resistance in human lung cancer cells is linked with dysregulation of cell cycle associated proteins

Horibe, Sayo, Matsuda, Akira, Tanahashi, Toshihito, Inoue, Jun, Kawauchi, Shoji, Mizuno, Shigeto, Ueno, Masaki, Takahashi, Kyohei, Maeda, Yusaku, Maegouchi, Tatsuya, Murakami, Yoshiki, Yumoto, Ryoko,

Journal:

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

40

Iontophoretic Transdermal Delivery of Salicylic Acid Dissolved in Ethanol-Water Mixture in Rats

Murakami, Teruo, Ihara, Chie, Kiyonaka, Gakuji, Yumoto, Ryoko, Shigeki, Sadayuki, Ikuta, Yushikazu, Yata, Noboru

Journal:

Skin Pharmacology and Applied Skin Physiology

Year:

1999

Language:

english

File:

PDF, 241 KB

english, 1999

41

Human Erythrocyte Nucleoside Transporter ENT1 Functions at Ice-cold Temperatures

Takano, Mikihisa, Kimura, Eri, Suzuki, Satoshi, Nagai, Junya, Yumoto, Ryoko

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 684 KB

english, 2010

42

Low-Affinity Transport of FITC-Albumin in Alveolar Type II Epithelial Cell Line RLE-6TN

Tagawa, Maki, Yumoto, Ryoko, Oda, Keisuke, Nagai, Junya, Takano, Mikihisa

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2008

Language:

english

File:

PDF, 2.48 MB

english, 2008

43

Effect of Thai Plant Extracts on P-glycoprotein Function and Viability in Paclitaxel-Resistant HepG2 Cells

Kawami, Masashi, Yumoto, Ryoko, Nagai, Junya, Junyaprasert, Varaporn Buraphacheep, Soonthornchareonnon, Noppamas, Patanasethanont, Denpong, Sripanidkulchai, Bung-orn, Takano, Mikihisa

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 562 KB

english, 2010

44

Receptor-mediated endocytosis of macromolecules and strategy to enhance their transport in alveolar epithelial cells

Takano, Mikihisa, Kawami, Masashi, Aoki, Ayako, Yumoto, Ryoko

Journal:

Expert Opinion on Drug Delivery

Year:

2015

Language:

english

File:

PDF, 768 KB

english, 2015

45

Flow Cytometry Analysis of Cancer Cell Death Induced by the Extract of Thai Plant Ellipeiopsis cherrevensis

Yumoto, Ryoko, Kakizoe, Saki, Nagai, Junya, Patanasethanont, Denpong, Sripanidkulchai, Bung-orn, Takano, Mikihisa

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2013

File:

PDF, 1.02 MB

2013

46

Flow Cytometry Analysis of Cancer Cell Death Induced by the Extract of Thai Plant Ellipeiopsis cherrevensis

Yumoto, Ryoko, Kakizoe, Saki, Nagai, Junya, Patanasethanont, Denpong, Sripanidkulchai, Bung-orn, Takano, Mikihisa

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

47

Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441

Takano, Mikihisa, Sugimoto, Natsumi, Ehrhardt, Carsten, Yumoto, Ryoko

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 2.46 MB

english, 2015

48

Methotrexate influx via folate transporters into alveolar epithelial cell line A549

Kawami, Masashi, Miyamoto, Mioka, Yumoto, Ryoko, Takano, Mikihisa

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2015

Language:

english

File:

PDF, 415 KB

english, 2015

49

Transport Mechanism of Nicotine in Primary Cultured Alveolar Epithelial Cells

Takano, Mikihisa, Nagahiro, Machi, Yumoto, Ryoko

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

50

Evaluation of In Vitro Dissolution and In Vivo Oral Absorption of Drug Nanopowders Prepared by Novel Wet-Milling Equipment

Tanaka, Yusuke, Inkyo, Mitsugi, Yumoto, Ryoko, Nagai, Junya, Takano, Mikihisa, Nagata, Shunji

Journal:

Current Nanoscience

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010